Photo credit: Daniil kuzelev/unsplash.com
Date: 6 July 2020
Institution: University of Sydney
Study published in: Science Advances
Digest: Researchers now pioneering a potentially sight-saving alternative to a cornea transplant by a biocompatible and adhesive liquid. It may remove the need for a cornea donor.
The cornea is the clear window that covers the front of the eye. When it is damaged corneal transplantation is required, however, this relies on donor human cornea of which there is a severe worldwide shortage.
University of Sydney researchers are part of the international team who have developed and carried out preclinical testing of a synthetic, biocompatible and adhesive liquid that aims to mend damaged cornea. The new clear gel, called LiQD Cornea, could potentially remove the need for transplants in many cases.
About 4,300 Australian’s suffer corneal injury each year and the figures are much higher in developing countries where agricultural accidents are a common cause.
“While we are more fortunate in Australia, only 1 in every 70 patients worldwide who need a corneal transplant get it,” said co-author Associate Professor Chameen Samarawickrama from the University of Sydney’s Faculty of Medicine and Health and The Westmead Institute for Medical Research.
Currently, damage to the cornea from physical trauma or infection, for example from a work-place injury or virus in the eye, is treated through sealing with a type of tissue glue (cyanoacrylate glue) from the superglue family. However, the glue is toxic and without follow-up corneal transplantation, there will still be sight loss.
Associate Professor Samarawickrama collaborated with colleagues at the University of Montreal (Canada) and Linkoping University (Sweden) on the conception and manufacturing of LiQD Cornea. He and post doctoral researcher Damien Hunter carried out a trial with rabbits, one of the two preclinical trials detailed in the paper, finding LiQD Cornea worked very effectively on smaller injuries.
“It comes out as a liquid and sets in a gel form, stays on the eye comfortably, doesn’t scar and remains see-through or translucent, countering many of the limitations of the tissue glue currently used. Our early studies also suggest it allows the eye to continue to regenerate.”
Due to the synthetic nature of the material, risks associated with immune rejection and disease transmission are also reduced in comparison to natural products.
While further preclincal studies are needed to ensure safety and efficacybefore progressing to human trials, Associate Professor Samarawickrama said the results are encouraging noting that the cornea is avascular (no blood vessels through it) in all mammals increasing the likelihood of similar outcomes in humans.
“If successful LiQD Cornea could be applied outside the operating room setting meaning there is immense potential to reduce health care costs and increase patient access,” he said.
Original written by: Michelle Blowes
Source: University of Sydney
Interested in original study: read here