Photo credit: Pexels/Pixabay.com
Date: 1 July 2020
Institution: Ludwig Maximilian University of Munich
Study published in : Nature
Digest: Plants collect and analyze information on the availability of water and nutrients or about the presence of pathogens. Researchers now mapped the signaling network in plants and discovered how plants process information about their environment. They experimentally tested more than 17 million protein pairs for physical interactions using a next-gen robotics pipeline combined with the latest bioinformatics methods. It can help to improve crop varieties in the future.
A team at the Institute of Network Biology at Helmholtz Zentrum München with the participation of LMU biologists charted the molecular protein network of plants by experimentally testing more than 17 million protein pairs for physical interactions using a next-gen robotics pipeline combined with latest bioinformatics methods. The network of more than 2,000 observed protein interactions was analyzed using bioinformatic mathematical approaches form statistics and graph theory to find the signaling pathways and potential information exchange points. This way the researchers identified hundreds of these points which were not known before.
Next, by using genetic tests, they could show that all tested information exchange points between proteins that were thought to function in single signaling pathways, in fact, organize the communication between different pathways. “This was one of the most striking new insights from this study: Most proteins function in multiple signaling pathways. Moreover, in contrast to single-gene analyses, our results revealed the high degree in which different pathways are physically and functionally intertwined. We believe that this is a fundamental principle and we need to pay more attention to it”, says Dr. Melina Altmann, first-author of the study.
Head of Studies Pascal Falter-Braun, Director of the Institute for Network Biology and Professor at the Ludwig-Maximilians-University, adds: “This insight might open new strategies for biotechnological development or breeding of plants to address the challenges of climate change in farming. We might be able to redirect the information in crops such that the plants require less fertilizer or pesticides or are more resistant against droughts.”
Interested in original study: read here